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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
13.03
Human Site:
T500
Identified Species:
22.05
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
T500
V
G
A
E
V
S
M
T
S
P
G
Q
S
K
N
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
T500
V
G
A
E
V
S
M
T
S
P
G
Q
S
K
N
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
T500
V
G
A
E
V
S
T
T
S
P
G
Q
S
K
N
Dog
Lupus familis
XP_534917
565
65190
T544
V
G
P
E
E
S
K
T
S
P
G
K
Q
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
E611
S
E
T
V
A
G
S
E
M
S
A
E
Q
Q
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
V556
L
G
S
K
L
P
P
V
V
G
I
A
S
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
S447
K
T
N
P
G
L
S
S
V
V
K
G
M
A
W
Chicken
Gallus gallus
Q5ZIU3
526
59419
L505
A
S
K
L
R
T
N
L
A
Q
M
T
D
A
N
Frog
Xenopus laevis
Q2TAE3
750
84138
S638
D
S
M
D
I
G
N
S
H
H
S
M
T
S
L
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
I608
G
E
R
S
V
Q
I
I
I
K
P
Q
T
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
K594
D
K
Y
N
S
M
Q
K
V
A
V
R
S
K
I
Honey Bee
Apis mellifera
XP_396369
614
68978
H576
L
N
G
S
A
S
S
H
A
L
A
S
S
T
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
P381
Y
G
L
L
A
Y
D
P
S
E
R
L
T
A
N
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
V765
A
T
G
G
A
D
S
V
D
I
G
A
I
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
53.3
N.A.
0
20
N.A.
0
6.6
0
13.3
N.A.
13.3
13.3
N.A.
N.A.
P-Site Similarity:
100
100
93.3
60
N.A.
20
46.6
N.A.
6.6
20
26.6
33.3
N.A.
20
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
22
0
29
0
0
0
15
8
15
15
0
22
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
0
8
0
8
8
0
8
0
0
0
8
0
0
% D
% Glu:
0
15
0
29
8
0
0
8
0
8
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
43
15
8
8
15
0
0
0
8
36
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
8
8
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
8
8
8
8
8
0
8
0
8
% I
% Lys:
8
8
8
8
0
0
8
8
0
8
8
8
0
36
15
% K
% Leu:
15
0
8
15
8
8
0
8
0
8
0
8
0
0
15
% L
% Met:
0
0
8
0
0
8
15
0
8
0
8
8
8
0
0
% M
% Asn:
0
8
8
8
0
0
15
0
0
0
0
0
0
0
36
% N
% Pro:
0
0
8
8
0
8
8
8
0
29
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
8
0
0
8
0
29
15
8
8
% Q
% Arg:
0
0
8
0
8
0
0
0
0
0
8
8
0
0
0
% R
% Ser:
8
15
8
15
8
36
29
15
36
8
8
8
43
22
15
% S
% Thr:
0
15
8
0
0
8
8
29
0
0
0
8
22
8
0
% T
% Val:
29
0
0
8
29
0
0
15
22
8
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
8
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _